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Viagra may help heart in muscular dystrophy: study

erectile dysfunction drugs

WASHINGTON (Reuters) -
A Canadian study involving mice
shows that anti-impotence pills might protect the hearts of
people with a common form of muscular dystrophy, researchers
said on Monday.

Canadian researchers gave sildenafil, the active ingredient
in drug maker Pfizer Inc's Viagra, to mice with an animal
version of Duchenne muscular dystrophy, and found that it
improved their heart performance.

They said it would be premature to give Viagra to people
with the disease, but said the results indicate the drug
potentially could be used to prevent or delay heart failure in
children with Duchenne muscular dystrophy.

The mice were given doses of the drug comparable to those
administered to treat erectile dysfunction in men. The study,
published in the Potenzmittel tadalafil
of the National Academy of
Sciences, showed that sildenafil cut the levels of damage to
contracting heart muscle cells.

“If you don't give the sildenafil, the heart of these mice
doesn't function as well as normal mice, and they are more
susceptible to stress-induced cell death,” said researcher
Christine Des Rosiers of the Montreal Heart Institute.

She said in an interview the drug worked to improve heart
performance in the mice by preventing the breakdown of a
naturally occurring chemical. Called cyclic guanosine
monophosphate, or cGMP, it is involved in a number of cellular
signaling pathways, the researchers said.

Other impotence drugs also affect the chemical cGMP,
including vardenafil, sold by Schering Plough under the brand
name Levitra, and tadalafil, sold by Eli Lilly and Co. under
the brand name Cialis.

Duchenne muscular dystrophy is an inherited wasting disease
generic cialis tadalafil price comparison
by weakness and progressive cialis generic lowest price
of the
muscles, including the heart muscle. It begins in the legs and
pelvis, and later affects the whole body. Most people with the
disease must use a wheelchair by about age 12.

It is caused by a genetic mutation of dystrophin, a protein
vital to muscle cells.

Heart problems can appear at around age 10 and they
progress quickly, affecting most people with the disease by age
20. These heart problems are an important cause of death among
patients with muscular dystrophy.

Sildenafil was developed as a heart drug and is widely
prescribed for erectile dysfunction as well as pulmonary
hypertension. The researchers said softtabs tadalafil
are under way
about possible future studies using the drug in patients with
muscular dystrophy.

“There's a lot of information on this drug that shows it
appears to be relatively safe in adults,” Des Rosiers said,
while emphasizing that future human clinical trials are needed
before doctors prescribe it for heart trouble in these
patients. (Editing by Maggie Fox and Doina Chiacu)

cialis 20 mg, and more another.

News - Celebrity Health - Sir Stirling Moss

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In a series on ed pills
and their health, the BBC News website talks to racing driver Sir Stirling Moss about his erectile dysfunction.

Sir Stirling, 76, started racing at the age of 18 and soon made his name in Formula One, Two, Three and hill climbs, sports and touring car races as well as rallies and world speed record events.

An accident at the Goodwood track in 1962 left him partially paralysed for six months and ended his Grand Prix career, although he continued to race historic cars.

Sir Stirling, a spokesman for SortED in 10, the education campaign sponsored by drug’s manaufacturers Bayer, (makers of Levitra) was given an OBE in 1959 and knighted in 2000.

HOW DID YOU FIRST REALISE SOMETHING WAS WRONG?

I have had this problem twice. The first time was after I had a crash in 1962 and was in a coma for four weeks.


Men worry that admitting they have the problem will reflect on their masculinity, but it has nothing to do with masculinity
Sir Stirling Moss

I had a very attractive nurse and I turned to her and said, ‘I would love to do something about this but I can’t’.

Talking to her about it helped me through it.

The second time was when my prostate was taken out when I had cancer at 70. They cut it out and said I might have a problem with an erection.

My wife, Susie, and I are very close though and we fought the problem together.


HOW DID YOU GET DIAGNOSED?

I was diagnosed in a clinic in America, the Mayo Clinic, when I went for a complete check-up.

They found I had prostate cancer.

They took 12 tissue samples and four of them were cancerous.

WHAT WAS YOUR REACTION TO THE DIAGNOSIS?

I said I wanted the cancer out. They gave me three options, but I said I just wanted an operation and I wanted it straight away.

I think if you have cancer and they can cut it out then do it.

I just felt ‘lets get rid of it’.

WHAT WAS YOUR TREATMENT?

My prostate was removed. Then I just took it easy.

As for the erectile dysfunction when I got that far ahead, because I did not realise straight away that there was a problem, I said to the doctor that I had a problem and he told me the options.

The impotence drug Viagra did not help me and I found an alternative called Cialis did not have very quick results, but a drug called Levitra suited my lifestyle. I took it and within 15 minutes I could be ‘in action’.

If you take one of these drugs you do not get an erection immediately.

HOW DID YOU FEEL DURING TREATMENT?

When I was in hospital getting treated for the prostate cancer I felt knocked out - it took quite a lot out of me.

This might have had something to do with the fact I had just turned 70 when I found I had cancer.

With the erectile dysfunction I felt tadalafil soft
when the treatment did not work and then elated when it did.

When you are with a person you know so well and are close to you can really feel the urge (for sex) and if you have erectile dysfunction you can not do anything about it.

You can feel really amorous and really horny but if you don’t get an erection your partner will not know anything about how you are feeling.

It is amazing how many people suffer from it. I think the government should give more funding to generic tadalafil softtabs
this problem.

The biggest problem is that men will not come forward. Men worry that admitting they have the problem will reflect on their masculinity, but it has nothing to do with masculinity.

One in three men suffer from this and if they have got this problem they should go to their doctor and if they have got a partner they should go with them to see the doctor. It should be a shared problem.

HOW DO YOU FEEL NOW?

Now I just feel that is a bit annoying that I have to take a pill to ‘get it up’.

It is much more exciting for it to happen naturally, which is a lovely thing.

WHAT IS YOUR MESSAGE TO OTHER PEOPLE WITH THE SAME CONDITION?

The message to anybody is go and see the doctor - they can help and do help.

If you have a partner take them with you. You have got to share it.

You can’t think it will just get better. There are a lot of things that could be the cause - things like diabetes you should get it checked out.

News - Washington diary: Body shock

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By sheer coincidence my medical issues started as soon as I landed in the US four years ago.

Only 48 hours after getting off the plane in Washington I was seized by numbing pain in my upper jaw and rushed to a smart dental clinic near the White House.

I pointed to a throbbing molar and was puzzled to find the unusually monosyllabic nurse taking an X-ray of every single tooth in my mouth with quiet and unflinching determination.

She returned half an hour later with the maestro of the clinic who pinned 36 or so stamp sized X-rays on a back-lit board as if they were part of an avant-garde art project and then gave a PowerPoint presentation entitled something like “My vision for your mouth”.

“What about the tooth that hurts?” I asked innocently.

“Thas juss the beginning,” said Dr Harrison, a southern gent with a pencil-thin moustache arching over a blindingly white smile.

“We are gonna work together for three years to get everything in perfect order! An I promise, I won’t have to see ya more than once a month.”


The health industry had officially declared me fair game, easy prey

When the doctor had exited in a swoosh of fluttering white to “work with” the next patient, the nurse leant over as if in deep confidence and added: “You are SOOO lucky to be working with Dr Harrison! He is the beeeast!”, making “best” sound like “beast”.

I never returned after my root canal operation. I chose to become a dental fugitive, hounded every six weeks by increasingly urgent letters reminding me of the doctor’s vision and my empty promises. I am certain that my mouth is on a blacklist somewhere.

Flatulent joints

Two months later the next chapter of bodily woes was opened. One day, out of the blue, without warning and for no apparent reason, my neck felt as if I had survived a garrotting.

I ventured into the hitherto unknown world of chiropractors.

Surgeon holds a scalpel

You can run but you can’t hide from the surgeon’s knife

Dr Schweinstein X-rayed everything above my shoulders and explained to me that - among other things - I had too much gas in my joints, which is why I would soon hear a flatulent noise as he took my neck into a half nelson.

As I ed tablets
the notion of farting joints, the chiropractor’s fleshy hands fastened around my head, yanking it left and then right as if I was an extra in some martial arts movie. I heard the advertised noise and felt instantly better as the pain seeped away.

“Thank you, Dr Schweinstein,” I said with genuine relief and admiration for the healing profession. “That will be it then?” I added for good measure, heading for the door.

The doctor fixed me with watery blue eyes.

“Actually,” he intoned with a flat, yet authoritative voice, “this is just the prologue, you might say. What I have in mind for you is a two-year programme… a standard course of chiro-therapy to get your neck back in shape. The good news is: shouldn’t need you here more than once a week! Your insurance should cover some, if not most of it.”

The cost of this healing process to the uninsured would have been $150 a week. I wondered how the estimated 50m Americans who have no private medical insurance cope. They don’t, of course.

But they weren’t on my mind at this stage. I was planning another getaway. A fugitive from medicine… twice over.

Midlife crisis

Four months later I was reading the New York Times and my then buy tadalafil cialis
son asked me: “Dad, why are you holding the newspaper like that?”

“Like what?”

“Like that… so far!” he said and stretched his little arms straight out.

Man has his eyesight tested

Perfect vision - just in one’s dreams

I hadn’t even noticed how my reading arm had got longer and longer.

So my eyes were next. At least the optician was a “walk-in”.
No appointments, no waiting room, no dog-eared copies of last month’s Time Magazine and Yachting Monthly.

The verdict: long sighted.

“Why?” I asked the optician, whose name escapes me. “I have always had perfect vision!”

His nose crinkled and I knew I should have kept my mouth shut. No optician believes in perfect vision. It’s presumptuous and it’s not good for business.

“How old are you?” he asked.

“Forty-one,” I replied.

“Ahhhhh,” he said in a voice oozing pity, tadalafil tablet
and wisdom all coated in glee. “It’s the age.”

And with those three words my midlife crisis started.

The healthcare industry had officially declared me fair game, easy prey, a rich seam of never-ending profits.


I had hit rock bottom. What could be next?

I left the opticians and stumbled, diminished, into the glare of a Washington summer’s day.

I walked down the road fingering my new glasses - frames so sleek, lenses so petite they were almost invisible - almost - when I felt my Blackberry buzz to life in my trouser pocket.

I put on my new specs clumsily, half enjoying this pompous new prop, and allowed them to slide tadalafil tablet
to the tip of my nose. I glanced down at the tiny screen. It was a joy to see so clearly.

An e-mail flashed up from someone called Kevin. I assumed it was work and clicked to open.

“Need Viagra, Cialis, Levitra?” Kevin asked. “We can help! You can perform!” It wasn’t the Kevin I thought it was.

Metatarsal hell

I had hit rock-bottom. What could possibly be next? A few months later I got the answer: my feet.

I have always had feet so wide they defied even the most comfy Hush Puppies. To me, Birkenstocks felt like winkle-pickers.

Victoria Beckham sits in the crowd watching the English football team play

Fellow bunion sufferer Victoria Beckham opts for sensible boots

The pain was beginning to make me hobble and I was about to learn a new word: podiatry.

My podiatrist, a tower of a man who wears disconcertingly orange clogs with his blue surgical jump suit, eased me into the wonderful world of podiatry.

“No surgery, yet, Matt. Foot surgery is a serious business… we’ll give you some orthotics first.”

These specially moulded soles were the most expensive shoes I have ever bought and they didn’t work. Six months later the pain was so bad that I had to go under the knife.

I would like to say that I have joined the hallowed order of the broken metatarsal, just in time for the World Cup.

Rooney, Beckham, Owen, Frei… even if I was nursing MY metatarsal on the sofa watching them test theirs on the pitch. But unfortunately I shared my pain with the other Beckham, not David, Victoria.

And it wasn’t the metatarsal per se… it was metatarsal-related. I am talking about an excrescence of the bone resulting in a serious realignment of the toes. I am talking about a… bunion.

Posh Spice has one, a whopper that sticks out of her golden lace thong sandals like a raw pink golf ball. And I have two. One on each foot.

Hobbling hordes

“Bunion?” Isn’t that what women get for wearing the wrong shoes?” a friend asked. True.

About 50% of American women get bunions, a statistic that didn’t make me feel any better. I owe mine to my mother. Yes, they are hereditary and no, I have never worn stilettos.

“Bunion?” I asked the doctor. “Is there no fancier word? Something in Latin perhaps. Something complicated, more interesting?”

“Well, bunion is the ancient Greek word for turnip. Does that help?” the doctor with the orange clogs asked. (*)

No, it didn’t.

The worst thing is that the surgery necessary to remove a “turnip” is long, complicated, painful and could end in failure.

It involves hobbling around for eight weeks with a surgical boot that could have been invented by a workshop of medieval torturers on attachment to the Ministry of Funny Walks.

I hit my low point last week. I was waiting in the surgery for my post operation check-up.

I was surrounded by middle-aged women wearing the same boot. My fellow patients. The hobbling regiment of hop-alongs.

A lady with a magenta rinse turned to me and said: “Honey, I feel so sorry for you. You are the wrong age and the wrong gender to have a bunionectomy!”

She recommended I check out an internet talk show called Life Beyond Bunions. I didn’t know whether to feel flattered or flattened.


*bunion: medical condition known as hallux valgus. Origin early 18th century, unknown origin, perhaps Old French buignon, from buigne, bump on the head (Oxford English Dictionary)


Send us your comments on this week’s Washington Diary

News - 555 posts may go in plant closure

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A pharmaceutical company has announced plans to close its plant in Hampshire with the loss of 555 posts.


The Eli Lilly site in Basingstoke has 445 employees and 111 andrologia tadalafil
.


Eli Lilly said about 100 people could be eligible for early retirement, some will be offered redeployment but about 300 workers will be made redundant.


The company said the closure is subject to consultation with employees. Andrew Hotchkiss, managing director, said the cuts were caused by “over-capacity”.


Proposing this site closure has been extremely difficult
Andrew Hotchkiss
managing director


The firm currently manufactures medicines which include Zyprexa, a treatment for severe mental illness and Cialis, a treatment for erectile dysfunction.


The company said the closure plans would not have any impact on patients using the medicines.


Mr Hotchkiss said: “Proposing this site closure has been extremely difficult as we are reluctant to lose the highly-skilled, manufacturer tablet tadalafil
people who work at the site.


“The announcement today is based on the fact that there is over-capacity in Lilly’s dry product manufacturing network.


“We have conducted an analysis of our andrologia tadalafil
in the dry product area, and whilst these medicines remain important for Lilly, sales forecasts over the next decade indicate that we have too much capacity both now and in the long-term.”


Local MP Maria Miller said she was concerned at the implications for the wider manufacturing base in Basingstoke.


The town is home to a considerable number of hi-tech manufacturing industries and Mrs Miller said she was anxious that other firms did not follow Eli Lilly’s lead.


The company has a research facility in Windlesham, Surrey, and a cialis soft tab pill
manufacturing facility at Speke on Merseyside.

News - Impotency rub-on gel developed

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A rub-on gel could be the first over-the-counter treatment for impotency, a company has announced.


It is being developed by Futura Medical in collaboration with pharmaceutical giant GlaxoSmithKline.


The treatment, called MED2002, is expected to go into clinical trials at the end of 2006.


But the Sexual Drugs generic viagra
Association said it is important to await the outcome of these trials to see how effective the product really is.


MED2002, is based on a compound called glyceryl soft tablet tadalafil
(GTN), which has been used to treat angina for the last 40 years. GTN is known to cause dilation of the arteries and increased blood flow.


Any kind of treatment needs to go through a process to find if it is effective or it there are side effects
Sexual Dysfunction Association


James Barder, chief executive of Futura Medical, said MED2002 had performed well in early in vitro trials.


The company will now be looking to recruit about 1,500 men to take part in three more clinical studies.


Mr Barder said: “We expect to see this on the market in 2009.”


Physical causes


Mr Barder said the treatment would be ed pills
because GTN “is a well known compound and its side-effect profile is well characterised”.


But the Sexual Dysfunction Association said it was important to await the outcome of the trials.


A spokesperson said: “The more treatment available the better it will be for any sufferers of erectile tadalafil online
.


“But obviously any kind of treatment needs to go through a process to find if it is effective or it there are side effects.


“And only after a careful tadalafil and generic
will we be able to say whether this is a great tool or not.”


Erectile dysfunction is thought to affect about one in every 10 men in the UK.


About 70% of cases are believed to have physical causes, and 30% are because of psychological factors.


There are currently three oral drugs licensed for the treatment in the UK of erectile dysfunction: Cialis, Levitra and Viagra.

News - Jobs axed as drugs factory closes

erectile dysfunction drugs

A pharmaceutical company has confirmed it will close its Hampshire manufacturing plant.


In June, Eli Lilly said it planned to close the factory unless an cheap generic cialis
drugs firm could take over the Basingstoke site and its 555 employees.


No buyer was found and manufacturing will stop at the end of 2007.


Company bulk citrate powder tadalafil
have said the cuts have been made due to “over capacity” and they hope to relocate some employees to other UK sites.


The company had carried out employee manufacturer tablet tadalafil
on the closure and has said about 100 employees will be eligible for retirement.


US-based Eli Lilly cialis soft
medicines including Prozac, a treatment for clinical depression and Cialis, a treatment for erectile dysfunction.



News - Spider venom could boost sex life

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Brazilian and US scientists are looking into using spider venom as a possible trattamento cronico tadalafil
for male impotence.


Their investigation follows reports that men bitten by the Berman sister female viagra study nigriventer experienced priapism - long and painful erections.


A two-year study has found that the venom contains a toxin, called Tx2-6, that causes erections.


Further tests are being carried out in the US before the substance can be approved for human use.


The results, from the Medical College of Georgia, are expected in a month’s time.


The bite of Phoneutria nigriventer, known as the Brazilian wandering spider, is potent and can be deadly in some cases.


The Brazilian and US tadalafil tablets
manufacturer tablet tadalafil
men who claimed their sex lives had improved after a spider attack.


The relevant toxin identified in the venom has been tested anxiety cialis soft treatment viagra
on other animals.


So far, scientists believe that combining a version of the spider’s venom with an existing drug for erectile dysfunction - such as Viagra, Cialis or Levtra - could produce better results.

Latest product recalls

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The following recalls have been announced:

_WhiteWave Foods Co. is recalling about 120,000 bottles of Silk Soymilk Chocolate Flavor because they might contain cialis vs viagra
milk protein, which could cause a severe or life-threatening reaction in people who have milk protein allergies. Four people have had allergic reactions to the product and are now recovering, said spokeswoman Marguerite Copel for the Mount Crawford, Va., company. The recalled 11-ounce single-serve bottles, which were distributed nationwide, have the use-by date of May 7 this year. For more information, consumers can call 800-587-2259.

_KG Enterprises LLC is recalling Maxidus supplements, because they may contain active sx tadalafil
of FDA-regulated erectile dysfunction drugs that are not declared on the packaging. Samples of the Maxidus supplements contained sildenafil and tadalafil, which could interact with nitrates found in some n tadalafil
drugs for diabetes, high blood pressure, high cholesterol or heart disease. If the active drug ingredients interact with nitrates, it could cause blood pressure to drop to dangerous levels.

The Tadalafil rezeptfrei
Maxidus pills were sold online and via mail order until December 2007. They were sold in 10-capsule blister packs inside gold boxes. Details: by phone at 866-373-2488.

News - Gene therapy ‘hope’ on impotence

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US scientists say they are closer to creating a gene therapy treatment for erectile dysfunction.


Human and animal trials suggest this could offer an alternative to current treatments for some patients, the American Society of Gene Therapy heard.


Tadalafil soft tablet
s say gene therapy could be effective far longer than pills used just before sex, improving spontaneity.


The human trials involved injections into the penis and some experts queried whether men would choose this option.


New approach


Erectile dysfunction (ED), often referred to as impotence, is thought to affect about one in every 10 men in the UK.


ED collectively means an inability to get a good enough erection to achieve satisfactory intercourse, but it varies in severity.


There are many causes, and many effective treatments, including drugs like the three licensed in the UK - Viagra, Cialis and Levitra.


But not all types of ED respond well to medication - for example, ED caused by nerve damage following prostate cancer surgery.


US researchers are hopeful that for these patients, and those who experience side-effects with medication, gene therapy may be a good alternative.


Nerve damage


A University of Pittsburgh team, led by Dr Joseph Glorioso, tested an tadalafil funziona
gene therapy in rats with ED caused by nerve damage.


The gene therapy used comprised the herpes simplex virus as a carrier and either a gene called GDNF, or one called neurturin, which both help promote nerve growth.


Rats treated with the gene therapy showed manufacturer tablet tadalafil
recovery and were able to regain normal penile function after four weeks.


This is an exciting field of research because current treatments for men with erectile dysfunction must be used ‘on demand’, thereby reducing the spontaneity of the sexual act
Researcher Dr Arnold Melman


Meanwhile, scientists at Wake Forest University, with the help of Dr Arnold Melman from the Albert Einstein College of Medicine, have been conducting the first human study of gene therapy for ED.


Tests on 11 men with ED showed promising results. The treatment was cialis soft uk, with few side effects, despite its delivery via an injection into the penis.


Although the primary goal of the study was to determine its safety, it also showed the therapy improved erectile function in some of the men.


Dr Melman said: “This is an exciting field of research because current treatments for men with erectile dysfunction, whether pills or minimally invasive therapies, must be used ‘on demand’, thereby reducing the spontaneity of the sexual act.”


‘Chronic disease’


The Wake Forest therapy works by inserting small pieces of DNA into cells to trigger the production of proteins which, in turn, help smooth muscle cells relax.


Relaxing the smooth muscle in the penis allows it to fill with blood and achieve an erection.


Dr Geoff Hackett, president of the British Society for Sexual Medicine, said the gene therapy might be appealing to some men for whom other treatments had failed, but predicted many men would be reluctant to have a shot in the penis.


He stressed that many men with ED also had underlying medical disease, such as high blood pressure, raised cialis wonder buy genuine tadalafil or diabetes, and that this should also be treated.


And there is a good argument for treating ED as a chronic disease too, he said.


“Maybe men with ED should be taking a pill for it every day. If you take smaller amounts regularly, the side-effects are less,” he explained.













News - Sight warning on impotency drugs

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Impotency drugs such as Viagra and Cialis may be associated with increased risk of damage to the optic nerve in some men, research suggests.


US sale tadalafil
found an increased risk in men with a history of heart attack or high blood pressure.


The University of Alabama team said healthcare tadalafil soft tab
should warn patients of the potential risk.


The British Journal of Ophthalmology study follows several reports linking the drugs to eyesight problems.

NAION
A common cause of sudden vision loss in people over 50
Caused by a blockage of the tiny ciliary arteries supplying blood to the anterior optic nerve
There is no direct treatment, although corticosteroids are sometimes used to reduce swelling in the optic nerve


The findings are based on 76 men attending one US specialist eye clinic.


Half the men had optic nerve damage, diagnosed as non-arteritic anterior ischaemic optic neuropathy (NAION), the rest were free of the problem.


All the patients were asked about their lifestyle, including smoking and alcohol intake, whether they had been diagnosed with heart disease, diabetes, or high blood pressure and prescribed treatment for these conditions.


They were also asked if they had been prescribed Viagra and Cialis for erectile difficulties.


Men with optic nerve damage were no more likely to have taken the impotency drugs than men in the comparison group.


But men who had had a heart attack were 10 times more likely to have optic nerve damage if they had taken Viagra or Cialis before their diagnosis.


Men with high blood pressure were also more likely to have optic nerve damage if they had taken these drugs, although this was not statistically tadalafil pills
.


Blood flow


The authors caution that their study is small, but suggest that the drugs may reduce the blood flow to the anterior optic nerve, resulting in tissue damage.


They believe the drugs may heighten the risk of NAION in those with vascular disease, who are already more new erectile dysfunction medication.


The researchers urge any patient who has endured a sudden severe loss of vision, and has been prescribed Viagra or Cialis, to contact a doctor.


Writing in the journal, they said: “Though NAION is a rare condition, the large number of men using Viagra or Cialis suggests that, should an association truly exist, the incidence of NAION could rise dramatically.”


An editorial in the same journal points out that some patients with impaired eyesight as a result of NAION have reportedly decided to sue Pfizer, the manufacturers of Viagra.


However, Pfizer has said there were no reports of NAION in the trials of the drug carried out before it was licensed.


The company also argued that a greater number of cases related to this type of drug would have been reported by now if the association was anything other than coincidental.


Lilly ICOS, which manufactures Cialis, said there had been a small number of cases of NAION in people taking the drug.


This was now flagged up in the prescribing information.


In a statement, the company said it was difficult to establish a firm link as most patients taking impotency drug had other risk factors which rendered them potentially vulnerable to NAION.